Features:A light-inducible and reversible inhibition system that promotes the aggregation of neurotransmitter-containing vesicles and suppresses vesicle secretion and release. Opto-vTrap can be widely applied in cells, brain slices, and in vivo. Activation of Opto-vTrap does not affect membrane potential but reversibly inhibits synaptic and glial transmission, reducing hippocampus-dependent memory retrieval, among other effects.