E-mail:BD@ebraincase.com
Tel:+8618971215294
English 中文版
Virus Vector - Viral Vector Production - BrainCaseVirus Vector - Viral Vector Production - BrainCase
  • Home
  • Virus product library
    CRISPRRNAiHSV-helperRV-helperNeurophilic virusCalcium SensorsOptogenetics activationOptogenetics inhibitionChemical geneticsSparse labelingFluorescent proteinBiosensorsRecombinaseApoptosis & AutophagyDisease ModelNeurotoxicityOther
  • Products & Service

    Product Center

    Virus

    VSV-circuit research-vaccine and gene therapy research-BrainCase
    Retrovirus-RCAS-TVA-BrainCase
    Lentivirus Vector - Lentivirus Production - BrainCase
    Rabies Virus Vector - RBV Vector - BrainCase
    Herpes simplex virus-Oncolytic and anterograde tracing-Brain Case
    PRV-retrograd multisynaptic-Peripheral-Btain Case
    AAV-gene therapy vectors-BrainCase

    Animal Model

    Neurological Disease Models-BrainCase
    Tumor animal models-anti-tumor-BrainCase
    Digestive System Disease Animal Model-Brain Case
    Cardiovascular System Disease Animal Models-Brain Case

    Plasmid Construction

    Bac
    Library Construction
    Plasmid design and construction

    Popular Applications

    Gene Regulation

    Gene Overexpression-Brain Case
    RNA interference(RNAi)-siRNA-Brain Case
    Gene Editing - CRSIPR cloning - BrainCase

    Neural Circuit Function Research

    Optogenetics - BrainCase
    Chemical genetics-DREADDs-Brain Case
    Calcium signal recording-Gels- Brain Case
    GRAB Neurotransmitter Fluorescent Probe- Brain Case
    Functional Magnetic Resonance Imaging Technology- Brain Case

    Research on the structure of neural circuits

    Direct Input and Output-viral vectors- Brain Case
    Anterograde Mono-synaptic Tracing -HSV- Brain Case
    Antrograde Muti-synaptic Tracing-HSV & VSV-Brain Case
    Retrograde Mono-synaptic Tracing-Rabies Virus-Brain Case
    Retrograde Muti-synaptic Tracing-PRV-Brain Case

    Featured Services

    Nervous System Disease Drug Effect

    Alzheimer's disease-AD-Brain Case
    Depression-mental disorders-Brain Case
    Parkinson's disease--PD-Brain Case
    Epilepsy-an ancient neurological disorder-Brain Case

    AAV Serotype Screening

    AAV Serotypes screening-gene therapy-Brain Case

    Tumorigenicity Test

    Tumorigenicity Testing-Evaluation of tumor models-Brain Case

    Efficacy of Oncolytic Virus

    Oncolytic virus-for cancer therapy-Brain Case
    Herpes Virus Vector-anti-tumor- BrainCase
    Vesicular stomatitis virus-killing tumor cells-Brain Case
  • News
    Corporate News New Product Launch Media Activity Investor News
  • Support
    Literature interpretation Customer article Video Zone FAQs
  • About Us
    Virus product library Products & Service News Support About Us Contact
  • Contact
    Contact Us Join us
  • 中文
    English 中文版
  • Home
  • Products & Service
  • Product Center
  • Virus
  • Virus
  • VSV-circuit research-vaccine and gene therapy research-BrainCase
  • Retrovirus-RCAS-TVA-BrainCase
  • Lentivirus Vector - Lentivirus Production - BrainCase
  • Rabies Virus Vector - RBV Vector - BrainCase
  • Herpes simplex virus-Oncolytic and anterograde tracing-Brain Case
  • PRV-retrograd multisynaptic-Peripheral-Btain Case
  • AAV-gene therapy vectors-BrainCase

VSV-circuit research-vaccine and gene therapy research-BrainCase (Vesicular stomatitis virus,VSV)

A vector utilized in vaccine and gene therapy research is the Vesicular Stomatitis Virus

Vesicular stomatitis virus (VSV) belongs to the genus Vesiculovirus of the family Rhabdoviridae, and is an enveloped single-stranded negative-sense RNA virus. Although VSV can replicate in the CNS, the use of VSV as a tracer virus was reported later than other viruses. After peripheral tissue infection, the body's innate immune system will quickly terminate the replication of VSV virus and clear it, so it is not suitable for marking the peripheral to central circuit, and it is widely used in central nervous circuit research.

VSV can infect a variety of animal models, including rodents, fish, birds, and non-human primates. It is characterized by fast replication and trans-synaptic speed, super high expression of exogenous genes, and fine morphology of neurons can be obtained.

The envelope glycoprotein (glycoprotein, G) of VSV is an essential protein for its anterograde cross-synapse. VSV without G protein (VSV-ΔG) will lose its ability to cross-synapse, while its genome replication and transcription will not be affected (it can continue to express foreign genes in high abundance). Therefore, VSV-ΔG virus can be used to quickly obtain a complete picture of the distribution of neuronal projections, and can also be used to develop an anterograde mono-transsynaptic tracer system.

Figure 1. Schematic diagram of VSV-specific forward transsynaptic transmission (Beier KT et al. Frontiers in Neural Circuits. 2013.)

Application

  • 1) CNS anterograde trans-multisynaptic labeling; 
  • 2) The central nervous system forwardly marks the primary output circuit;
  • 3) Interferon activity detection, pseudovirus (a common method for vaccine evaluation) and gene therapy research, etc.

Product list

Serie No. Product name Illustration
BC-VSV-Vs03 VSV-EYFP anterograde,Green
BC-VSV-Vs13 VSV-mCherry anterograde,Red
BC-VSV-Vs28 VSV-WT Wild type,no color
BC-VSV-Vs31 VSV-∆G-EYFP Transformable pseudoviruses and oncolytic viruses
BC-VSV-Vs33 VSV-∆G Functional components can be added, Transformable pseudoviruses and oncolytic viruses
 

If you're interested in the modification and application of VSV, please click on the small window in the bottom right corner or send an email to BD@ebraincase.com to contact us.


💥Holiday

Special

Offers

Click to fill in the requirements and submit them to us!

Service Type :

Select the service you'd like to purchase.

Order Information(Premade-AAVs)

Please provide us some information about the service you'd like to order.

Detailed requirements:

scroll

Order Information(Custom AAV/Lentivirus)

Please provide us some information about the service you'd like to order.

Gene ID or gene information:

Selection of the reporting gene:

Special Instructions:

scroll

Order Information(Others)

Please provide us some information about the service you'd like to order.

Virus name/Detailed requirements:

scroll

Related products

AAV-gene therapy vectors-BrainCase

AAV-gene therapy vectors-BrainCase

Lentivirus Vector - Lentivirus Production - BrainCase

Lentivirus Vector - Lentivirus Production - BrainCase

Herpes simplex virus-Oncolytic and anterograde tracing-Brain Case

Herpes simplex virus-Oncolytic and anterograde tracing-Brain Case

Rabies Virus Vector - RBV Vector - BrainCase

Rabies Virus Vector - RBV Vector - BrainCase

map
{dede:global.cfg_webname/}

Virus product library

CRISPR
RNAi
Neurophilic virus
Optogenetics activation
Biosensors

News

Corporate News
New Product Launch
Media Activity
Investor News

Support

Literature interpretation
Customer article
Video Zone
FAQs
微信

WhatsApp Business Account

Tel: +8618971215294
E-mail: BD@ebraincase.com

Address:-

Address:-

  • Copyright © 2024 Brain Case All Rights Reserved.