Features:Parathyroid hormone receptor 1 (PTH1R) is an important member of Class B GPCRs, highly expressed in bones and kidneys. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) are two endogenous peptide hormones that specifically bind to PTH1R, activating downstream signaling pathways and regulating calcium-phosphate metabolism in the body. These processes are crucial for maintaining skeletal development and bone metabolism.